Jackie Shapiro launched her design career after graduating from Parson's School of Design. Her first job landed her in Italy, working for Milan's innovative fashion house Fiorucci, where she began to develop her bold and graphic, pop culture style. Returning to New York, she began freelancing for Tommy Hillfiger, and later went on to design for Itokin, one of Japan's largest fashion manufacturers. Jackie began her own children's fashion collection, "Izzy", known for it's stylized mix of pattern and color, and featured in top stores such as Henri Bendel's, Saks and Fred Segal.

Mattel Inc. has commissioned Jackie's talents since 1997 for many of their Barbie products. She also works closely with Cartoon Network's consumer products division on the Power Puff Girls and Hi Hi Puffy Ami Yumi brands. French Bull, a contemporary melamine housewares brand and Tepper Jackson, a pajama and bag collection, are Jackie's most recent transition into designing for the home and accessory markets.